Meloholic is the type of drama where you can skip half of the episodes and you'd still be able to understand what happened.
Why? Because it's a bunch of clichés thrown together with an unoriginal serial murder mystery, a dangerous mental illness that is taken as a joke, and a ridiculous love story.

Story/Plot
Pfft. Is there even a plot/story? From the first episode, you'd probably be able to predict the ending scene. There was an absence of character development and twists.
Ye Ri's DID was unrealistic, and portrayed as some sort of jest. Every aspect of it made me roll my eyes to another dimension, particularly when she "transformed".
The characters were copies of each other: bland, dense and slow. Even the killer was inadequate.
I couldn't believe in Ye Ri and Eun Ho's love, there was no build up and it seemed forced.

Acting/Cast
I have never watched a drama with U-know and Kyung Soo Jin, but it's pretty obvious to me that Kyung Soo Jin did a better job. At least she was able to play two distinct personalities.  U-know could barely act out his one character.

Music
Didn't really pay attention to the music. Actually, the only time I did when Another Miss Oh's OST was playing at Ye Ri's cafe.

Rewatch Value
Um.. No. There's no reason to watch it in the first place.

Overall
Meloholic is the perfect drama to watch when you're looking to facepalm, roll your eyes and curse at utterly stupid characters that lack common sense.

No, but seriously. Find something better to watch.