I second dele and Inseparable bros they are both amazing.
My mister - FL's grandmother can't walk nor speak
Silenced - it takes place in a school for hearing-impaired children (but it is a very heavy movie, probably the saddest I have seen in general so beware and don't watch it if you are not feeling good.)
Hot stove league - the ML's brother is bound to a wheelchair but he is not shown very much especially in the beginning.
My annoying brother - ML is blind
- ml cant recognize faces
- fl cant hear well
- blind ml
- mute fl
- fl in wheel chair but only in last episodes
- fl changes personalities
- stuttering fl
- ml cant touch other people
- blind fl
- ml very low iq
- fl had some problems with her personality not sure if it counts
- deaf ml
- brother of fl authism/low iq
Unforgettable: if I remember correctly the FL can't really walk, she has to limp.
Physical
Hitsudan Hostes (Movie): FL is deaf
Someone Like You: ML is blind
My Annoying Brother (movie): ML is blind
Always (movie): FL is blind
Page Turner: FL is blind
Angels Last Mission: FL is blind
Two Lights: Relumino (movie): leads both have visual impairments
Melting Me Softly: FL’s brother is wheelchair bound.
School Nurse Files: ML has limp
Mental
Perfume: ML has lots of allergies and phobias, FL has low self-esteem
Devilish Joy: character has amnesia
Be Melodramatic: one of the main characters has schizophrenia
Age of Youth/Hello My Twenties S2: one of the main characters has PTSD, side character has autism
Missing: The Other Side: FL has PTSD, side character has developmental disability
Kill Me, Heal Me and Hyde, Jekyll, Me: ML has DID
Good Doctor: ML is autistic
The Beauty Inside: ML has prosopagnosia
Romantic Doctor Teacher Kim: FL struggles with mental illness, suicidal tendencies
Hello Monster: multiple characters have Antisocial Personality Disorder
It’s Okay, That’s Love: everyone has issues (ML has OCD and schizophrenia, SML has autism)
The K2: ML has PTSD